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The Amoeboid Revolution was a historical event in the Ratchet & Clank Universe that lasted for three days from the 9th of March to the 11th. Although the reason behind the revolt wasn't said, it may have had something to do with Dr. Nefarious as it began on the day of his birthday and that he was known to create Amoeboids. The uprising was quickly halted once it had been discovered table salt could be used to reduce Amoeboids to gooey sludge. The Amoeboid Revolution was mentioned on the Ratchet & Clank 2010 Calendar.

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